Lupus Panniculitis in Children: A Rare Finding

Authors

  • Muhammad Ashfaq National Institute of Child Health, Rafique Shaheed Road Karachi, 75510, Pakistan.
  • Muniba Jalil National Institute of Child Health, Rafique Shaheed Road Karachi, 75510, Pakistan.
  • Bader U Nisa National Institute of Child Health, Rafique Shaheed Road Karachi, 75510, Pakistan.
  • Aijaz Ahmed National Institute of Child Health, Rafique Shaheed Road Karachi, 75510, Pakistan.
  • Sajid Ali National Institute of Child Health, Rafique Shaheed Road Karachi, 75510, Pakistan.

DOI:

https://doi.org/10.36570/jduhs.2023.3.1848

Keywords:

Child, Lupus Erythematosus, Panniculitis

Abstract

Lupus panniculitis (LP) is a rare condition that primarily affects adults and is even more uncommon in the
pediatric population. This rarity, combined with variable clinical presentations and limited diagnostic approaches
in children, often leads to its misdiagnosis or being overlooked. Recently, a case involving a six year's old boy
demonstrated the importance of recognizing early skin manifestations and providing timely treatment. The child
was presented with painful swelling in the right hand and erythematous plaques on the face and trunk. Although
the autoimmune workup yielded weakly positive results, a skin biopsy was performed, which confirmed the
diagnosis of LP. This case report serves to emphasize the significance of identifying early skin manifestations and
the advancements in diagnostic methods that aid in accurate diagnosis.

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References

Polcari IC, Stein SL. Panniculitis in childhood. Dermatol Ther 2010; 23:356-67. doi:10.1111/j.1529-8019.2010.01336.x

Peters MS, Su WP. Lupus erythematosus panniculitis. Med Clin North Am 1989; 73:1113-26. doi:10.1016/s0025-7125(16)30622-8

Rangel LK, Villa-Ruiz C, Lo K, Cobos G, Lo Sicco K, Vleug-els RA, et al. Clinical characteristics of lupus erythematosus panniculitis/profundus: a retrospective review of 61 patients. JAMA Dermatol 2020; 156:1264-6. doi:10.1001/jamadermatol.2020.2797

Verdier M, Anuardo P, Gormezano NW, Romiti R, Cam-pos LM, Aikawa NE, et al. Panniculitis in childhood-onset systemic lupus erythematosus: a multicentric cohort study. Adv Rheumatol 2019; 59:3. doi:10.1186/s42358-019-0049-9

Zhao YK, Wang F, Chen WN, Xu R, Wang Z, Jiang Y W, et al. Lupus panniculitis as an initial manifestation of systemic lupus erythematosus: A case report. Medicine (Baltimore) 2016; 95: e3429. doi:10.1097/MD.0000000000003429

Weingartner JS, Zedek DC, Burkhart CN, Morrell DS. Lupus erythematosus panniculitis in children: report of three cases and review of previously reported cases. Pediatr Dermatol 2012; 29:169-76. doi:10.1111/j.1525-1470.2011.01544.x

Zhang R, Dang X, Shuai L, He Q, He X, Yi Z. Lupus erythematosus panniculitis in a 10-year-old female child with severe systemic lupus erythematosus: A case report. Medicine (Baltimore) 2018; 97:e9571. doi:10.1097/MD.0000000000009571

Cojocaru M, Cojocaru IM, Silosi I, Vrabie CD. Manifesta-tions of systemic lupus erythematosus. Maedica 2011; 6:330.

Schur PH, Kammer GM. 18 Treatment of Systemic Lupus. Modern Therapeutics in Rheumatic Diseases Humana Press, Totowa, NJ 2001; 259.

Kopp A, Buechler C, Neumeier M, Weigert J, Aslanidis C, Scholmerich J, et al. Innate immunity and adipocyte function: ligand-specific activation of multiple Toll-like receptors modulates cytokine, adipokine, and chemokine secretion in adipocytes. Obesity (Silver Spr-ing) 2009; 17:648-56. doi:10.1038/oby.2008.607

Kono DH, Haraldsson MK, Lawson BR, Pollard KM, Koh YT, Du X, et al. Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus. Proc Natl Acad Sci USA 2009; 106:12061-6. doi:10.1073/pnas.0905441106

Sari AR, Ferronika P, Soebono H, Yogianti F. Lupus panniculitis: a rare bilateral and symmetrical manifestation of cutaneous lupus erythematosus in an adolescent girl. Dermatol Reports 2022; 15:9515. doi:10.4081/dr.2022.9515

Bednarek A, Bartoszak L, Samborski W. Case report on a patient with lupus panniculitis. Postepy Dermatol Alergol 2015; 32:59-62. doi:10.5114/pdia.2014.40958

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Published

2023-10-30

How to Cite

Ashfaq, M., Jalil, M., U Nisa, B., Ahmed, A., & Ali, S. (2023). Lupus Panniculitis in Children: A Rare Finding. Journal of the Dow University of Health Sciences (JDUHS), 17(3). https://doi.org/10.36570/jduhs.2023.3.1848

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Section

Case Report

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