Vitamin D Deficiency in Children with and without Cystic Fibrosis: A Cross-Sectional Study

Authors

  • Rehmat Bughio National Institute of Child Health, Rafique Shaheed Road Karachi, Pakistan
  • Aijaz Ahmed National Institute of Child Health, Rafique Shaheed Road Karachi, Pakistan
  • Muhammad Ashfaq National Institute of Child Health, Rafique Shaheed Road Karachi, Pakistan
  • Bader U Nisa National Institute of Child Health, Rafique Shaheed Road Karachi, Pakistan
  • Wajid Hussain National Institute of Child Health, Rafique Shaheed Road Karachi, Pakistan

DOI:

https://doi.org/10.36570/jduhs.2020.3.1007

Keywords:

Vitamin D status, Children, Cystic fibrosis

Abstract

Objective: To compare the vitamin D deficiency in children with and without cystic fibrosis.

Methods: This case-control study was conducted at National Institute of Child Health (NICH) Karachi, Pakistan from October 2018 to April 2019. All children of age ranged 10 months to 15 years of either gender were consecutively enrolled. Cases were defined as children diagnosed with cystic fibrosis irrespective of duration of symptoms whereas controls were apparently healthy children attended outpatient department with no severe disease and had recent vitamin D level report. Cystic fibrosis was confirmed based on sweat chloride test at the time of presentation. A sweat chloride test result of ≥60 mmol/L along with clinical features suggests cystic fibrosis. Serum 25-OHD <20 ng/ml was classified as vitamin D deficiency.

Results: Of total 93 patients (31 with cystic fibrosis and 62 without cystic fibrosis), the overall median age of the patients was 10 (5-11) years. There were 29 (31.2%) males and 64 (68.8%) females. The median vitamin D level was significantly lower in patients with cystic fibrosis as compared to the patients without cystic fibrosis, i.e. (15 (12-25) ng/ml and 29 (22-32) ng/ml respectively, p-value <0.001. Vitamin D deficiency showed that of 93 patients, 37 (39.8%) patients had vitamin D deficiency. Moreover, Vitamin D deficiency was significantly higher in cystic fibrosis patients as compared to without cystic fibrosis patients, i.e. 23 (74.2%) and 14 (22.6%) respectively (p-value <0.001).

Conclusion: A considerably higher number of patients with cystic fibrosis had low level of vitamin D.

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References

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Published

2020-12-17

How to Cite

Bughio, R., Ahmed, A., Ashfaq, M., Nisa, B. U., & Hussain, W. (2020). Vitamin D Deficiency in Children with and without Cystic Fibrosis: A Cross-Sectional Study. Journal of the Dow University of Health Sciences (JDUHS), 14(3), 114–118. https://doi.org/10.36570/jduhs.2020.3.1007

Issue

Vol. 14 No. 3

Section

Original Articles

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Copyright (c) 2020 Rehmat Bughio, Aijaz Ahmed, Muhammad Ashfaq, Bader U Nisa, Wajid Hussain

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