Addressing Treatment Abandonment in Pediatric Oncology: The Role of Missed Appointment Call-Back Systems in a Pakistani Setting

Authors

  • Neelum Tahirkheli Department of Paediatric Haematology Oncology, Indus Hospital and Health Network, Karachi.
  • Sadia Imran Department of Paediatric Haematology Oncology, Indus Hospital and Health Network, Karachi.
  • Fauzia Ahmed Department of Paediatric Haematology Oncology, Indus Hospital and Health Network, Karachi.
  • Muhammad Rafi Raza Department of Paediatric Haematology Oncology, Indus Hospital and Health Network, Karachi.
  • Zaman Khan Department of Paediatric Haematology Oncology, Indus Hospital and Health Network, Karachi.
  • Shabnam Munir Department of Paediatric Haematology Oncology, Indus Hospital and Health Network, Karachi.
  • Muhammad Shamvil Ashraf Department of Paediatric Haematology Oncology, Indus Hospital and Health Network, Karachi.
  • Syed Ahmed Hamid Department of Paediatric Haematology Oncology, Indus Hospital and Health Network, Karachi.

Keywords:

Pediatric cancer, Treatment abandonment, call-back system, Pakistan, oncology

Abstract

Objective: To evaluate the effectiveness of a missed appointment call-back system in reducing treatment abandonment rates at a tertiary care hospital in Pakistan.
Methods: This cross-sectional study was conducted in the Pediatric Hematology and Oncology Department of Indus Hospital and Health Network from April to September 2023. The study included children aged 1 month to 16 years diagnosed with cancer and receiving curative treatment. A call-back system was introduced, contacting patients within 48 hours of a missed appointment to address their absence and reschedule. Treatment abandonment was defined as missing clinic visits for 4 weeks.
Results: Of 389 children, the mean age was 6.8 ±4.0 years. There were 258 (66.3%) males and 131 (33.6%) females. Treatment abandonment was observed in 26 (6.7%) patients. The likelihood of treatment abandonment was 6 times significantly higher in children who did not respond to the call than those who did respond (cOR 6.27, 95% CI 2.69 to 14.59, p-value <0.001). Similarly, children who missed rescheduled appointments had 8 times higher chances of treatment abandonment than those who attended (cOR 8.11, 95% CI 3.30 to 19.92, p-value <0.001). Among 26 treatment abandonment children, the most common reason of missed appointment was financial issue 10 (38.5%) followed by forget appointment 7 (26.9%), attending school 6 (23.1%), and long distance 3 (11.5%).
Conclusion: Treatment abandonment was low as 6.7%. Children who did not respond to call-backs or missed rescheduled appointments were significantly more likely to abandon treatment. The call-back system is effective in reducing abandonment rates in pediatric oncology.

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References

Wu Y, Deng Y, Wei B, Xiang D, Hu J, Zhao P, et al. Global, regional, and national childhood cancer burden, 1990-2019: An analysis based on the Global Burden of Disease Study 2019. J Adv Res 2022; 40:233-47. doi:10.1016/j.jare.2022.06.001

Badar F, Mahmood S. Epidemiology of cancer in Lahore, Pakistan, among children, adolescents and adults, 2010-2012: A cross-sectional study part 2. BMJ Open 2017; 7:e016559. doi:10.1136/bmjopen-2017-016559

Johnston WT, Erdmann F, Newton R, Steliarova-Foucher E, Schüz J, Roman E. Childhood cancer: Estimating regional and global incidence. Cancer Epidemiol 2021; 71:101662. doi:10.1016/j.canep.2019.101662

Gatta G, Botta L, Rossi S, Aareleid T, Bielska-Lasota M, Clavel J, et al. EUROCARE Working Group. Childhood cancer survival in Europe 1999-2007: Results of EUROCARE-5-a population-based study. Lancet Oncol 2014; 15:35-47. doi:10.1016/S1470-2045(13)70548

Siddiqui DE, Ashraf MS, Iftikhar S, Belgaumi AF. Predic-tors of treatment abandonment for patients with pediatric cancer at Indus Children Cancer Hospital, Karachi, Pakistan. Pediatr Blood Cancer 2018; 65:e26818. doi:10.1002/pbc.26818

Friedrich P, Lam CG, Itriago E, Perez R, Ribeiro RC, Arora RS. Magnitude of treatment abandonment in childhood cancer. PLoS One 2015; 10:e0135230. doi:10.1371/journal.pone.0135230

Palagyi A, Balane C, Shanthosh J, Jun M, Bhoo-Pathy N, Gadsden T, et al. Treatment abandonment in children with cancer: Does a sex difference exist? A systematic review and meta-analysis of evidence from low- and middle-income countries. Int J Cancer 2021; 148:895-904. doi:10.1002/ijc.33279

Ocran Mattila P, Ahmad R, Hasan SS, Babar ZU. Availab-ility, affordability, access, and pricing of anti-cancer medicines in low- and middle-income countries: A systematic review of literature. Front Public Health 2021; 9:628744. doi:10.3389/fpubh.2021.628744

Jabeen K, Ashraf MS, Iftikhar S, Belgaumi AF. The impact of socioeconomic factors on the outcome of childhood acute lymphoblastic leukemia (ALL) treatment in a low/middle income country (LMIC). J Pediatr Hematol Oncol 2016; 38:587-96. doi:10.1097/MPH.0000000000000653

Lan BN, Castor A, Wiebe T, Toporski J, Moell C, Hagander L. Adherence to childhood cancer treatment: A prospective cohort study from Northern Vietnam. BMJ Open 2019; 9:e026863. doi:10.1136/bmjopen-2018-026863

Seah T, Zhang C, Halbert J, Prabha S, Gupta S. The magn-itude and predictors of therapy abandonment in pediatric central nervous system tumors in low- and middle-income countries: Systematic review and meta- analysis. Pediatr Blood Cancer 2019; 66:e27692. doi:10.1002/pbc.27692

Pribnow AK, Ortiz R, Baez LF, Mendieta L, Luna-Fineman S. Effects of malnutrition on treatment-related morbidity and survival of children with cancer in Nicaragua. Pediatr Blood Cancer 2017; 64. doi:10.1002/pbc.26590

Ferman S, Lima FFDS, Lage CRS, da Hora SS, Vianna DT, Thuler LC. Preventing treatment abandonment for children with solid tumors: A single-center experience in Brazil. Pediatr Blood Cancer 2019; 66:e27724. doi:10.1002/pbc.27724

Vasquez L, Diaz R, Chavez S, Tarrilo F, Maza I, Hernandez E, et al. Factors associated with abandonment of thera-py by children diagnosed with solid tumors in Peru. Pediatr Blood Cancer 2018; 65:e27007. doi:10.1002/pbc.27007

Salaverria C, Rossell N, Hernandez A, Fuentes Alabi S, Vasquez R, Bonilla M, et al. Interventions targeting absences increase adherence and reduce abandonment of childhood cancer treatment in El Salvador. Pediatr Blood Cancer 2015; 62:1609-15. doi:10.1002/pbc.25557

Jatia S, Prasad M, Paradkar A, Bhatia A, Narula G, Chinnaswamy G, et al S. Holistic support coupled with prospective tracking reduces abandonment in childhood cancers: A report from India. Pediatr Blood Cancer 2019; 66:e27716. doi:10.1002/pbc.27716

Mostert S, Arora RS, Arreola M, Bagai P, Friedrich P, Gupta S, et al. Abandonment of treatment for childhood cancer: position statement of a SIOP PODC Working Group. Lancet Oncol 2011; 12:719-20. doi:10.1016/S1470-2045(11)70128-0

Slone JS, Chunda-Liyoka C, Perez M, Mutalima N, New-ton R, Chintu C, et al. Pediatric malignancies, treatment outcomes and abandonment of pediatric cancer treatment in Zambia. PLoS One 2014; 9:e89102. doi:10.1371/journal.pone.0089102

Alvarez E, Seppa M, Rivas S, Fuentes L, Valverde P, Antillón-Klussmann F, et al. Improvement in treatment abandonment in pediatric patients with cancer in Guatemala. Pediatr Blood Cancer 2017; 64. doi:10.1002/pbc.26560

Graetz D, Rivas S, Fuentes L, Caceres-Serrano A, Ferrara G, Antillon-Klussmann F, et al. The evolution of parents' beliefs about childhood cancer during diagnostic communication: a qualitative study in Guatemala. BMJ Glob Health 2021; 6:e004653. doi:10.1136/bmjgh-2020-004653

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Published

2024-12-13

How to Cite

Tahirkheli, N., Imran, S., Ahmed, F., Rafi Raza, M., Khan, Z., Munir, S., Shamvil Ashraf, M., & Ahmed Hamid, S. (2024). Addressing Treatment Abandonment in Pediatric Oncology: The Role of Missed Appointment Call-Back Systems in a Pakistani Setting. Journal of the Dow University of Health Sciences (JDUHS), 18(3), 131–136. Retrieved from https://jduhs.com/index.php/jduhs/article/view/2194

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