Comparison of Fibrosis-4 with FibroScan for Liver Fibrosis Assessment in Non-Alcoholic Fatty Liver Disease Patients: A Cross-sectional Study

Authors

  • Fahad Kakar Department of Gastroenterology, Patel Hospital, Karachi, Pakistan.
  • Arif Rasheed Siddiqui Department of Gastroenterology, Patel hospital, Karachi, Pakistan.
  • Saad Khalid Niaz Department of Gastroenterology, Patel Hospital, Karachi, Pakistan.
  • Syed Afzal ul Haq Haqqi Department of Gastroenterology, Patel Hospital, Karachi, Pakistan.
  • Zea ul Islam Farrukh Department of Gastroenterology, Patel hospital, Karachi, Pakistan.
  • Muhammad Danish Ashraf Wallam Department of Gastroenterology, Patel hospital, Karachi, Pakistan.
  • Muhammad Umar Farooq Department of Gastroenterology, Patel hospital, Karachi, Pakistan.
  • Sayed Rohail Ahmed Rizvi Department of Gastroenterology, Patel Hospital, Karachi, Pakistan.

Keywords:

Aspartate Aminotransferases, Alanine, Fibrosis, Liver Cirrhosis, Non Alcoholic Fatty Liver Disease, Transaminase

Abstract

Objective: To compare the efficacy and accuracy of the Fibrosis-4 (FIB-4) index with FibroScan in assessing liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD).Methods: This cross-sectional study was conducted at Patel Hospital, Karachi, Pakistan, from October 2023 to April 2024. All known cases of NAFLD or non-alcoholic steatohepatitis (NASH) aged ≥18 years, regardless of gender, were included. FIB-4 scores were measured using age, platelet level, aspartate transaminase (AST), and alanine transaminase (ALT). FibroScan categorized liver fibrosis into stages F0 to F4 with specific stiffness ranges: F0 (1–6 kPa), F1 (6.1–7 kPa), F2 (7.1–9 kPa), F3 (9.1–10.3 kPa), and F4 (≥10.4 kPa).Results: Of the 146 patients, the median age was 52.00 (IQR: 47.00–54.00) years. Based on FibroScan results, 61 (41.8%) patients were classified as F1, 35 (24.0%) as F2, 30 (20.5%) as F3, and 20 (13.7%) as F4. The diagnostic performance of FIB-4 showed an area under the curve of 0.83 (95% CI: 0.76–0.90). The optimal cut-off for FIB-4 was 1.28 with sensitivity, specificity, positive predictive value, negative predictive value, and overall diagnostic accuracy of 98.0%, 65.6%, 59.7%, 98.4%, and 76.7%, respectively. Spearman's correlation test (ρ) was applied and a significantly moderate correlation was found between FibroScan and FIB-4 (ρ = 0.50, p < 0.001).Conclusion: FIB-4 demonstrated higher accuracy and diagnostic performance in determining liver fibrosis in NAFLD patients compared to FibroScan.

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Published

2024-08-09

How to Cite

Kakar, F., Siddiqui, A. R., Niaz, S. K., ul Haq Haqqi, S. A., Farrukh, Z. ul I., Ashraf Wallam, M. D., Farooq, M. U., & Ahmed Rizvi, S. R. (2024). Comparison of Fibrosis-4 with FibroScan for Liver Fibrosis Assessment in Non-Alcoholic Fatty Liver Disease Patients: A Cross-sectional Study. Journal of the Dow University of Health Sciences (JDUHS), 18(2), 79–83. Retrieved from https://jduhs.com/index.php/jduhs/article/view/2167

Issue

Vol. 18 No. 2

Section

Original Articles

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