The Impact of COVID-19 on Asthma Patients: Current Knowledge and Future Perspective

Authors

  • Muhammad Farooq Sabar Centre for Applied Molecular Biology, University of the Punjab, Lahore-Pakistan
  • Sana Ashiq Centre for Applied Molecular Biology, University of the Punjab, Lahore-Pakistan, 53700.
  • Mariam Shahid Centre of Excellence in Molecular Biology, University of the Punjab, Lahore-Pakistan.

Keywords:

Asthma, Covid-19, Genetics, Treatment

Abstract

The pandemic of CoronaVirus-19 (COVID-19) is an alarming situation worldwide as it poses a considerable threat to the healthcare system. Various study results suggested the effect of COVID-19 on non-communicable diseases (NCDs) including asthma. The present study aims to review, describe and assess the impact of COVID-19 on asthma patients. The results of the current review suggest a non-significant impact of asthma on COVID-19 outcomes. However, the impact of COVID-19 on asthmatics is complex that may vary according to the clinical severity, patient age, or genetics in different populations. Hence it is needed to conduct studies with a large number of cohorts in different populations that may provide us with conclusive results. The use of corticosteroids is not recommended, but some studies suggested that by monitoring certain factors corticosteroids can be used for COVID-19 patients suffering from asthma. The future care of asthmatic patients in COVID-19 should include self-management, remote interventions, and social distancing.

Downloads

Download data is not yet available.

References

Aslam R, Shahid M, Bano I, Ayoub M, Sabar MF, Altaf S, et al. Major histocompatibility complex class II polymorphic variants are associated with asthma predisposition in the Punjabi population of Lahore, Pakistan. Clin Respir J 2021;15:374-81.

doi: 10.1111/crj.13309 Saba

MF, Ghani MU, Shahid M, Sumrin A, Ali A, Akram M, et al. Genetic variants of ADAM33 are associated with asthma susceptibility in the Punjabi population of Pakistan. J Asthma 2016; 53:341-8. doi: 10.3109/02770903.2015.1124441Sabar

MF, Shahid M, Bano I, Ghani MU, Akram M, Iqbal F, et al. rs12603332 is associated with male asthma patients specifically in urban areas of Lahore, Pakistan. J Asthma 2017; 54:887-92. doi: 10.1080/02770903.2016.1277539Von d

Thusen, J, Van der Eerden M. Histopathology and gen-etic susceptibility in COVID‐19 pneumonia. Eur J Clin Invest 2020; 50:e13259.

doi: 10.1111/eci.13259

Morais - Almeida M, Pite H, Aguiar R, Ansotegui I, Bousquet J. Asthma and the coronavirus disease 2019 pandemic: a literature review. Int Arch Allergy Immunol 2020;181:680-8. doi: 10.1159/000509

Rothan HA, Byrareddy SN. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J Autoimmun 2020;109:102433. doi: 10.1016/j.jaut.2020.102433

Tsang HF, Chan LW, Cho WC, Yu AC, Yim AK, Chan AK, et al. An update on COVID-19 pandemic: the epidemiology, pathogenesis, prevention and treatment strategies. Expert Rev Anti Infect Ther 2021; 19:877-88. doi: 10.1080/14787210.2021.1863146

Ghosh S, Das S, Mondal R, Abdullah S, Sultana S, Singh S, et al. A review on the effect of COVID-19 in type 2 asthma and its management. Int Immunopharmacol 2021; 91:107309. doi: 10.1016/j.intimp.2020.107309

Liu S, Zhi Y, Ying S. COVID-19 and asthma: reflection during the pandemic. Clin Rev Allergy Immunol 2020; 59:78-88. doi: 10.1007/s12016-020-08797-3

Caminati M, Vultaggio A, Matucci A, Senna G, Almerigogna F, Bagnasco D, et al. Asthma in a large COVID-19 cohort: prevalence, features, and determinants of COVID-19 disease severity. Respir Med 2021; 176:106261. doi: 10.1016/j.rmed.2020.106261

Song J, Zeng M, Wang H, Qin C, Hou HY, Sun ZY, et al. Distinct effects of asthma and COPD comorbidity on disease expression and outcome in patients with COVID‐19. Allergy 2021; 76:483-96. doi: 10.1111/all.14517

Lee SC, Son KJ, Han CH, Jung JY, Park SC. Impact of comorbid asthma on severity of coronavirus disease (COVID-19). Sci Rep 2020; 10:1-9. doi: 10.1038/s41598-020-77791-8

Liu S, Cao Y, Du T, Zhi Y. Prevalence of comorbid asthma and related outcomes in COVID-19: a systematic review and meta-analysis. J Allergy Clin Immunol Pract 2020; 9: 693-701. doi: 10.1016/j.jaip.2020.11.054

Lovinsky-Desir S, Deshpande DR, De A, Murray L, Stingone JA, Chan A, et al. Asthma among hospitalized patients with COVID-19 and related outcomes. J Allergy Clin Immunol 2020; 146:1027-34. doi: 10.1016/j.jaci.2020.07.026

Hussein MH, Elshazli RM, Attia AS, Nguyen TP, Abou-eisha M, Munshi R, et al. Asthma and COVID-19; different entities, same outcome: a meta-analysis of 107,983 patients. J Asthma 2021:1-8. doi: 0.1080/02770903.2021.1881970

Hussein MH, Toraih EA, Attia AS, Youssef M, Omar M, Burley N, et al. Asthma in COVID-19: An extra chain fitting around the neck? Respir Med 2020; 175:106205. doi: 10.1016/j.rmed.2020.106205

Zhu Z, Hasegawa K, Ma B, Fujiogi M, Camargo CA, Liang L. Association of asthma and its genetic predisposition with the risk of severe COVID-19. J Allergy Clin Immunol 2020; 146:327-9. doi: 10.1016/j.jaci.2020.06.001

Peters MC, Sajuthi S, Deford P, Christenson S, Rios CL, Montgomery MT, et al. COVID-19–related genes in sputum cells in asthma. Relationship to demographic features and corticosteroids. Am J Respir Crit Care Med 2020; 202:83-90. doi: 10.1164/rccm.202003-0821OC

Kermani NZ, Song WJ, Badi Y, Versi A, Guo Y, Sun K, et al. Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma. Respir Res 2021; 22:1-0. doi: 10.1186/s12931-020-01605-8

Kasela S, Ortega VE, Martorella M, Garudadri S, Nguyen J, Ampleford E, et al. Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium. Genome Med 2021;13:1-7. doi: 10.1186/s13073-021-00866-2

Kumar K, Hinks TS, Singanayagam A. Treatment of COVID-19-exacerbated asthma: should systemic corticosteroids be used? Am J Physiol Lung Cell Mol Physiol 2020; 318:244-47. doi: 10.1152/ajplung.00144.2020

Maes T, Bracke K, Brusselle GG. COVID-19, asthma, and inhaled corticosteroids: another beneficial effect of inhaled corticosteroids? Am J Respir Crit Care Med 2020; 202:1-10. doi: 10.1164/rccm.202005-1651ED

Beaney T, Salman D, Samee T, Mak V. Assessment and management of adults with asthma during the covid-19 pandemic. BMJ 2020;369. doi: 10.1136/bmj.m2092

Hasan S S, Capstick T, Zaidi ST, Kow CS, Merchant HA. Use of corticosteroids in asthma and COPD patients with or without COVID-19. Respir Med 2020; 170:106045. doi: 10.1016/j.rmed.2020.106045

Hughes Visentin A, Paul ABM. Asthma and COVID-19: What do we know now. Clin Med Insights Circ Respir Pulm Med 2020;14. doi: 10.1177/1179548420966242

Hartman-Boyce J, Gunnell J, Darke J, Otunla A, Sukan J, Schofield E, et al. Asthma and COVID-19: review of evidence on risks and management considerations. BMJ Evid Based Med 2020; 1-8. doi: 10.1136/bmjebm-2020-111506

Taquechel K, Diwadkar AR, Sayed S, Dudley JW, Grundmeier RW, Kenyon CC, et al. Pediatric asthma health care utilization, viral testing, and air pollution changes during the COVID-19 pandemic. J Allergy Clin Immunol Pract 2020; 8:3378-87. doi: 10.1016/j.jaip.2020.07.057

Kaye L, Theye B, Smeenk I, Gondalia R, Barrett MA, Stempel DA. Changes in medication adherence among patients with asthma and COPD during the COVID-19 pandemic. J Allergy Clin Immunol Pract 2020;8(7):2384-85. doi: 10.1016/j.jaip.2020.04.053

Downloads

Published

2022-04-22

How to Cite

Sabar, M. F., Ashiq, S., & Shahid, M. . (2022). The Impact of COVID-19 on Asthma Patients: Current Knowledge and Future Perspective. Journal of the Dow University of Health Sciences (JDUHS), 16(1), 41–45. Retrieved from https://jduhs.com/index.php/jduhs/article/view/1616

Issue

Section

Commentary