Circulating Levels of Adipokines and TNF in Patients with and without Type 1 Diabetes

Authors

  • Anila Jaleel Shalamar Medical and Dental College Lahore
  • Adnan Zuberi Chemical Pathology, Ziauddin University, Karachi, Pakistan.
  • Bilal Aheed Department of Biochemistry, Ziauddin University, Karachi, Pakistan.
  • Shahnila Jaleel Department of Biochemistry, Ziauddin University, Karachi, Pakistan.

Keywords:

HOMA-IR, Adiponectin, Resistin, Visfatin, Insulin

Abstract

Objective: The aim of this study was to evaluate circulating levels of adiponectin, resistin, visfatin and TNF in type1 diabetic children and young adolescents.

Patients and Methods:
Design: Cross-sectional study
Setting: Ziauddin University Karachi Subjects: 90 subjects (30 type I diabetic (T1DM) subjects and 60 non-diabetic controls) between the age of 05-15 years.
Methods: Serum adiponectin, resistin, visfatin, TNF and insulin were measured using ELISA and fasting blood sugar by glucose oxidase (Standard Kit method).

Results: Out of 90 study subjects, 30 were type 1 diabetic patients and 60 non-diabetic controls. Increased levels of serum adiponectin levels were significant in type I diabetic subjects (TIDM) (10.83+1.73) compared with controls (9.07+1.25). Same pattern was observed for serum TNF in diabetic subjects (10.82+4.53) compared with controls (7.22+ 2.22). Significantly increased serum visfatin levels were found in TIDM patients (10.89+2.72) compared with controls (4.97+1.57). Significant negative correlation was observed between TNF and resistin (r=-0.356), adiponectin and age (r= - 0.594), and glucose and insulin in TIDM patients (r= -0.588). Binary logistic shows significant association of HOMA IR, adiponectin and visfatin with Type 1 diabetes mellitus.
Level of significance set for the study was P=0.05.
Conclusion: Increased levels of circulating adipocytokines in Type I diabetic children depict the important role of cytokines in Type I diabetic patients. However, increased adiponectin concentration in type I diabetic subjects needs to be further explored in large-scale studies.

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Published

2013-04-28

How to Cite

Jaleel, A., Zuberi, A., Aheed, B., & Jaleel, S. (2013). Circulating Levels of Adipokines and TNF in Patients with and without Type 1 Diabetes. Journal of the Dow University of Health Sciences (JDUHS), 7(1), 10–14. Retrieved from https://jduhs.com/index.php/jduhs/article/view/1557

Issue

Vol. 7 No. 1

Section

Original Articles

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Copyright (c) 2021 Anila Jaleel, Adnan Zuberi, Bilal Aheed, Shahnila Jaleel

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