Comparison of the Efficacy and Cost-effectiveness of Highly Purified Urinary Follicle Stimulating Hormone (HP-uFSH) and Recombinant Follicle Stimulating Hormone (rFSH) in Poor Responders

Authors

  • Mustafa Kara Bozok University Medical Faculty, Department of Obstetrics and Gynecology, Adnan Menderes Boulevard Yozgat, Turkey.
  • Kenan Sofuoglu Zeynep Kamil Women's and Childern's Hospital, Reproductive Medicine and IVF Unit, Ystanbul.
  • Tayfun Kutlu Zeynep Kamil Women's and Childern's Hospital, Reproductive Medicine and IVF Unit, Ystanbul.
  • Belgin Devranoglu Zeynep Kamil Women's and Childern's Hospital, Reproductive Medicine and IVF Unit, Ystanbul.
  • Tansel Centinkaya Zeynep Kamil Women's and Childern's Hospital, Reproductive Medicine and IVF Unit, Y stanbul.

Keywords:

Follicle stimulating hormone, luteinizing hormone, ovulation induction, in vitro fertilization, embryo transfer

Abstract

Aim:

We aimed to compare the clinical results and effectiveness of two gonadothropin treatment protocols;
HP-uFSH and rFSH in poor responders.
Materials and Methods:

While HP-uFSH was given to 58 patients, rFSH was given to 62 patients. The patientselection criteria were the same (FSH value > 15 iu/l or antral follicle number < 4, on the second day of menstruation).
Results:

Endometrial thickness on hCG day (mm) was 9.0 ± 2.7 and 7.8 ± 2.7 in HP-uFSH group and rFSH group, respectively and this difference was statistically significant. Contrarily, fertilization rate (%) was better in rFSH than HP-uFSH (76.6 ± 15.9 vs. 68.2 ± 17.8) and this value was also statistically significant. Percentage of cancelled cycles (%) was 14 ± 34 in HP-uFSH group and this parameter was significantly lower than rFSH group (29 ± 45).
Conclusion:

rFSH is as efficacious as HP-uFSH in poor responders. Fertilization rate was better in rFSH than HP-uFSH. Since rFSH is more expensive, the final treatment cost with rFSH to obtain a pregnancy was slightly higher, but this difference was not statistically significant (20060 TL vs. 17150 TL).

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Published

2011-08-28

How to Cite

Kara, M., Sofuoglu, K., Kutlu, T., Devranoglu, B., & Centinkaya, T. (2011). Comparison of the Efficacy and Cost-effectiveness of Highly Purified Urinary Follicle Stimulating Hormone (HP-uFSH) and Recombinant Follicle Stimulating Hormone (rFSH) in Poor Responders. Journal of the Dow University of Health Sciences (JDUHS), 5(2), 43–46. Retrieved from https://jduhs.com/index.php/jduhs/article/view/1502

Issue

Vol. 5 No. 2

Section

Original Articles

License

Copyright (c) 2021 Mustafa Kara, Kenan Sofuoglu, Tayfun Kutlu, Belgin Devranoglu

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Articles published in the Journal of Dow University of Health Sciences are distributed under the terms of the Creative Commons Attribution Non-Commercial License https://creativecommons.org/ licenses/by-nc/4.0/. This license permits use, distribution and reproduction in any medium; provided the original work is properly cited and initial publication in this journal.