Therapeutic Effect of Aegiceras corniculatum in Chronic Granulomatous Inflammation and Arthritis

Authors

  • Talat Roome Molecular Pathology, Department of Pathology, Dow Diagnostic Reference and Research Laboratory, Dow International Medical College, Dow University of Health Sciences Karachi, Pakistan.
  • Anam Razzak Molecular Pathology, Department of Pathology, Dow Diagnostic Reference and Research Laboratory, Dow International Medical College, Dow University of Health Sciences Karachi, Pakistan.
  • Perbhat Ali Molecular Pathology, Department of Pathology, Dow Diagnostic Reference and Research Laboratory, Dow International Medical College, Dow University of Health Sciences Karachi, Pakistan.
  • Sabahat Aziz Molecular Pathology, Department of Pathology, Dow Diagnostic Reference and Research Laboratory, Dow International Medical College, Dow University of Health Sciences Karachi, Pakistan.
  • Ahsana Dar H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan.
  • Sabira Naqvi H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan.
  • Muhammad Iqbal Choudhary H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan.

Keywords:

Chronic inflammation, Aegiceras corniculatum, anti-inflammatory, immuno-modulatory activity

Abstract

Objective:

Chronic inflammation is a result of long lasting of acute inflammation, if not treated or resolved,this condition is a cause of many inflammatory and autoimmune diseases. Aegiceras corniculatum a mangroveplant has been using for many years for the treatment of many inflammatory and autoimmune diseases likeatherosclerosis, rheumatoid arthritis, asthma and is well known as a folklore medicine constituting variousnovel chemical constituents.

Methodology:

Methanol and ethyl acetate extracts derived from A. corniculatum were evaluated againstchronic inflammation by using cotton pellet induced granuloma and Adjuvant induced arthritis models in rats.Vascular permeability and leukocyte migration were studied in the presence of extracts.

Results:

In cotton pellet granuloma, both the methanol and ethanol extracts were found to highly effectivein reducing granulomatous tissue formation in a dose dependent manner. These extracts also suppressed thepaw thickness induced by using adjuvant in rat arthritis model, at maximum oral dose of 50 mg/kg methanolextract inhibited swelling in paw by 67%, whereas ethyl acetate extract caused 75% of inhibition in pawswelling at 200 mg/kg. Additionally, ethyl acetate extract has shown inhibition in leukocytes migration (63%at 50 mg/kg) against LTB4 and carrageenan. However, methanol extract failed to produce inhibitory effectagainst cell infiltration induced by LTB4. Interestingly, methanol and ethyl acetate extract has shown remarkablereduction in the acetic acid induced vascular permeability.

Conclusion:

A. corniculatum extracts has shown remarkable effect as an anti-arthritic and anti-inflammatoryagent to combat with chronic inflammatory diseases, this study provides significant justification for its folkloremedical use against rheumatism interfering with inflammatory and cellular immune responses.

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References

Vane J., Botting R. Inflammation and the mechanism of action of anti-inflammatory drugs. FASEB journal: official publication of Fed Am Soc Exp Biol 1987; 1:89-96.

Jiang Q., Ames B. N. Gamma-tocopherol, but not alpha-tocopherol, decreases proinflammatory eicosanoids and inflammation damage in rats. FASEB journal : official publication of the Fed Am Soc Exp Biol 2003; 17:816-22.

Willerson JT, Ridker PM. Inflammation as a cardiovascular risk factor. Circulation 2004; 109:II2-10.

Bandaranayake WM. Traditional and medicinal uses of mangroves. Mangroves and Salt Marshes 1998; 2:133-48.

Roome T, Dar A, Naqvi S, Ali S, Choudhary MI. Aegiceras corniculatum extract suppresses initial and late phases of inflammation in rat paw and attenuates the production of eicosanoids in rat neutrophils and human platelets. J Ethnopharmacol 2008; 120:248-54.

Roome T, Dar A, Ali S, Naqvi S, Choudhary MI. Astudy on antioxidant, free radical scavenging, antiinflammatory and hepatoprotective actions of Aegiceras corniculatum (stem) extracts. J Ethnopharmacol 2008; 118:514-21.

Roome T, Dar A, Naqvi S, Choudhary MI. Evaluation of antinociceptive effect of Aegiceras corniculatum stems extracts and its possible mechanism of action in rodents. J Ethnopharmacology 2011; 135:351-8.

Bandaranayake WM. Bioactivities, bioactive compounds and chemical constituents of mangrove plants. Wetlands Ecology and Management 2002; 10:421-52.

Zhang D, Wu J, Zhang S, Huang J. Oleanane triterpenes from Aegiceras corniculatum. Fitoterapia. 2005; 76:131-3.

Zaoui A, Cherrah Y, Mahassini N, Alaoui K, Amarouch H, Hassar M. Acute and chronic toxicity of Nigella sativa fixed oil. hytomedicine. Int J Phytotherapy Phytopharmacol 2002; 9:69-74.

Akhila J, Shetty; Deepa, Shyamjith; Alwar MC. Acute toxicity studies and determination of median lethal dose. Current Science 2007; 93:917.

Winter CA, Porter CC. Effect of alterations in side chain upon anti-inflammatory and liver glycogen activities of hydrocortisone esters. J Am Pharm Assoc 1957; 46:515-9.

Babu NP, Pandikumar P, Ignacimuthu S. Antiinflammatory activity of Albizia lebbeck Benth, an ethnomedicinal plant, in acute and chronic animal models of inflammation. J Ethnopharmacol 2009; 125:356-60.

Whittle BA. The Use of Changes in Capillary Permeability in Mice to Distinguish between Narcotic and Nonnarcotic Alalgesics. Br J Pharmacol Chem 1964; 22:246-53.

Neto AG, Costa JM, Belati CC, Vinholis AH, Possebom LS, Da Silva Filho AA, et al. Analgesic and antiinflammatory activity of a crude root extract of Pfaffia glomerata (Spreng) Pedersen. J Ethnopharmacol 2005; 96:87-91.

Ribeiro RA, Flores CA, Cunha FQ, Ferreira SH. IL-8 causes in vivo neutrophil migration by a cell-dependent mechanism. Immunol 1991; 73:472-7.

Swingle KF, Shideman FE. Phases of the inflammatory response to subcutaneous implantation of a cotton pellet and their odification by certain anti-inflammatory agents. J Pharmacol Exp Therapeutics 1972; 183:226-34.

Whaley K, Burt AD. Inflammation, healing and repair. London: Arnold; 1996.

Zidek Z, Frankova D, Holy A. Chemokines, nitric oxide and antiarthritic effects of 9-(2-phosphonomethoxy ethyl) adenine (Adefovir). Eu J Pharmacol 1999; 376:91-100.

Nantel F, Denis D, Gordon R, Northey A, Cirino M, Metters KM, et al. Distribution and regulation of cyclooxygenase-2 in carrageenan-induced inflammation. Br J Pharmacol 1999; 128:853-9.

Rao KV, Bose PK. Genin-A and isorhamnetin fromthe bark of Aegiceras majus Gaertn. J Ind Chem Soc 1959; 36:358–60.

Hensens OD, Lewis KG. Extractives of the bark of Aegiceras corniculatum. Aus J Chem 1966; 19:169-74.

De Duve C. Lysosomes in pathology and therapeutics.; Japan: Abstracts of the International Symposium on Lysosomes Hakone 1972.

De Duve C, Wattiaux R. Functions of lysosomes. Annual review of physiology 1966; 28:435-92.

Rang HP, Dale MM, Ritter JM. Textbook of Pharmacology: Churchill Livingstone UK 1999.

Burt AD, Smith TW. Healing and repair.: Thomas Press Ltd India 2001.

Okoli CO, Akah PA, Nwafor SV, Anisiobi AI, Ibegbunam IN, Erojikwe O. Anti-inflammatory activity of hexane leaf extract of Aspilia africana CD. Adams. J Ethnopharmacol 2007; 109:219-25.

Brown JN, Roberts J. Histamine, bradykinin, and their antagonists. Newyork: McGraw Hill Co 2001.

Di Rosa M, Papadimitriou JM, Willoughby DA. A histopathological and pharmacological analysis of the mode of action of nonsteroidal anti-inflammatory drugs. J Pathol 1971; 105:239-56.

Vinegar R, Schreiber W, Hugo R. Biphasic development of carrageenin edema in rats. J Pharmacol Exp Therapeutics 1969; 166:96-103.

Crunkhorn P, Meacock SC. Mediators of the inflammation induced in the rat paw by carrageenin. Br J Pharmacol 1971; 42:392-402.

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Published

2014-12-31

How to Cite

Roome, T. ., Razzak, A. ., Ali, P., Aziz, S. ., Dar, A. ., Naqvi, S., & Iqbal Choudhary, M. . (2014). Therapeutic Effect of Aegiceras corniculatum in Chronic Granulomatous Inflammation and Arthritis. Journal of the Dow University of Health Sciences (JDUHS), 8(3), 98–103. Retrieved from https://jduhs.com/index.php/jduhs/article/view/1429

Issue

Vol. 8 No. 3

Section

Original Articles

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Copyright (c) 2021 Talat Roome, Anam Razzak, Perbhat Ali, Sabahat Aziz, Ahsana Dar, Sabira Naqvi, Muhammad Iqbal Choudhary

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Articles published in the Journal of Dow University of Health Sciences are distributed under the terms of the Creative Commons Attribution Non-Commercial License https://creativecommons.org/ licenses/by-nc/4.0/. This license permits use, distribution and reproduction in any medium; provided the original work is properly cited and initial publication in this journal.