Biochemical and Hematological Profile of Anemic And Non-Anemic Pregnant Women
DOI:
https://doi.org/10.36570/jduhs.2020.2.995Keywords:
Biochemical, Anemia, Hematology, Pregnant WomenAbstract
Objective:To determine the biochemical and hematological profile of pregnant women with and without anemia attending Sanderman Provincial Hospital, Quetta.
Methods : This descriptive cross-sectional study was conducted among pregnant women aged ranged from 18 to 48 years attending the antenatal clinic for the first-time during February 2019 to August 2019. Hematological parameters like white blood cells (WBC), hemoglobin (Hb), hematocrit (HCT), Red blood cell distribution width (RDW), mean corpuscular hemoglobin concentration (MCHC), and mean corpuscular volume (MCV) were collected. Furthermore, biochemical parameters like serum ferritin and iron level, total iron-binding capacity (TIBC), Transferrin saturation (TfS), total bilirubin, direct bilirubin, and indirect bilirubin were also noted.
Results : Of 357 patients, the mean Hb level was 10.27 ±1.53 g/dl. Majority of the pregnant were anemic, i.e. 248 (69.5%). Of these 248 anemic patients, mild anemia was found in 135 (54.4%), moderate anemia in 100 (40.3%) and severe anemia in 13 (5.2%) patients. A significantly lower level of Hb (p-value <0.001), WBC (p-value), HCT (p-value <0.001), MCHC (p-value <0.001), MCV (p-value <0.001), and RDW (p-value <0.001) was observed in patients with anemia as compared to non-anemic patients. Moreover, serum ferritin level (p-value 0.002), serum iron (p-value <0.001), and total bilirubin level (p-value <0.001) were found to be significantly lower in anemic patients than non-anemic patients.
Conclusion : Anemia in pregnant women is associated with considerably low level of hematological and biochemical levels. Health providers should give attention to pregnant women with lower hematological and biochemical levels to prevent maternal and fetal complications.
Downloads
References
doi: 10.1016/S2214-109X(13)70001-9
2. Balarajan Y, Ramakrishnan U, Ozaltin E, Shankar AH, Subramanian SV. Anaemia in low-income and middle-income countries. Lancet. 2011;378(9809):2123–35.
doi: 10.1016/S0140-6736(10)62304-5
3. Datta S, Kodali BS, Segal S. Maternal physiological changes during pregnancy, labor, and the postpartum Period. Obstetric Anesthesia Handbook. New York: Springer; 2010; 1-14.
4. Inam-ul-Haq AM, Anwar B, Saleem MA. Hematological Profile of Healthy Pregnant Females in Association with Parity. J Rawal Med Coll. 2013;17:98-100.
doi: 10.1002/14651858.CD004945.pub4.
5. Akinlaja O. Hematological changes in pregnancy-The preparation for intrapartum blood loss. Obstet Gynecol Int J. 2016;4(3):00109.
6. Ahenkorah B, Nsiah K, Baffoe P, Anto EO. Biochemical and hematological changes among anemic and non-anemic pregnant women attending antenatal clinic at the Bolgatanga regional hospital, Ghana. BMC hematology. 2018 18(1):27. doi: 10.1186/s12878-018-0121-4
7. Bleyere MN, Néné-Bi AS, Kone M, Sawadogo D, Yapo PA. Iron status and red cell parameters in pregnant and non-pregnant adolescents in Côte d’Ivoire (West Africa). International Blood Research & Reviews. 2014:8-22.
8. Baig-Ansari N, Badruddin SH, Karmaliani R, Harris H, Jehan I, Pasha O, et al. Anemia prevalence and risk factors in pregnant women in an urban area of Pakistan. Food Nutr Bull. 2008;29(2):132-9. doi: 10.1177/156482650802900207
9. Ullah A, Sohaib M, Saeed F, Iqbal S. Prevalence of anemia and associated risk factors among pregnant women in Lahore, Pakistan. Women Health. 2019 Jul 3;59(6):660-71. doi: 10.1080/03630242.2018.1544966.
10. Suryanarayana R, Santhuram AN, Chandrappa M, Shivajirao P, Rangappa SS. Prevalence of anemia among pregnant women in rural population of Kolar district. Int J Med Sci Public Health. 2016 Mar 1;5(3):454-8. doi: 10.18203/2320-1770.ijrcog20173605
11. Sharma S, Kaur SP, Lata G. Anemia in Pregnancy is Still a Public Health Problem: A Single Center Study with Review of Literature. Indian J Hematol Blood Transfus. 2020;36(1):129-34. doi: 10.1007/s12288-019-01187-6
12. Grum T, Brhane E, Hintsa S, Kahsay G. Magnitude and factors associated with anemia among pregnant women attending antenatal care in public health centers in central zone of Tigray region, northern Ethiopia: a cross sectional study. BMC pregnancy and childbirth. 2018;18(1):433. doi: 10.1186/s12884-018-2063-z
13. Brhanie TW, Sisay H. Prevalence of Iron deficiency Anemia and determinants among pregnant women attending antenatal Care at Woldia Hospital, Ethiopia. J Nutr Dis Ther. 2016;6(4). doi: 10.7754/Clin.Lab.2018.180822
14. Alene KA, Dohe AM. Prevalence of Anemia and Associated Factors among Pregnant Women in an Urban Area of Eastern Ethiopia. Cairo: Hindawi Publishing Corporation; 2014.
15. Getahun W, Belachew T, Wolide AD. Burden and associated factors of anemia among pregnant women attending antenatal care in southern Ethiopia: cross sectional study. BMC Res Notes. 2017;10:276. doi: 10.1186/s13104-017-2605-x.
16. Mihiretie H, Fufa M, Mitiku A, Bacha C, Getahun D, Kejela M, et al. Magnitude of Anemia and Associated Factors among Pregnant Women Attending Antenatal Care in Nekemte Health Center, Nekemte, Ethiopia. J Med Microbiol Diag. 2015;4(3). doi: 10.4172/2161-0703.1000197
17. Zekarias B, Meleko A, Hayder A, Nigatu A, Yetagessu T. Prevalence of Anemia and its associated factors among pregnant Women Attending antenatal care (ANC) in Mizan Tepi University teaching hospital, South West Ethiopia. Health Sci J. 2017;11(5,529).
18. Derso T, Abera Z, Tariku A. Magnitude and associated factors of anemia among pregnant women in Dera District: a cross-sectional study in Northwest Ethiopia. BMC Res Notes. 2017;10:359. doi: 10.1186/s13104-017-2690-x
19. Gebre A, Mulugeta A. Prevalence of Anemia and associated factors among pregnant women in North Western zone of Tigray, northern Ethiopia: a cross-sectional study. J Nutr Metab. 2015;2015:165430. doi: 10.1155/2015/165430.
20. Wemakor A. Prevalence and determinants of anaemia in pregnant women receiving antenatal care at a tertiary referral hospital in Northern Ghana. BMC Pregnancy Childbirth. 2019;19(1):495. doi: 10.1186/s12884-019-2644-5.
21. James TR, Reid HL, Mullings AM. Are published standards for haematological indices in pregnancy applicable across populations: an evaluation in healthy pregnant Jamaican women. BMC Pregnancy Childbirth. 2008;8(1):8. doi:10.1186/1471-2393-8-8
22. Anchang-Kimbi JK, Nkweti VN, Ntonifor HN, Apinjoh TO, Chi HF, Tata RB, et al. Profile of red blood cell morphologies and causes of anaemia among pregnant women at first clinic visit in the mount Cameroon area: a prospective cross sectional study. BMC Res Notes. 2017;10(1):645. doi: 10.1186/s13104-017-2961-6.
23. Susanti AI, Sahiratmadja E, Winarno G, Sugianli AK, Susanto H, Panigoro R. Low hemoglobin among pregnant women in midwives practice of primary health care, Jatinangor, Indonesia: Iron deficiency Anemia or β-thalassemia trait? Anemia. 2017:5. doi: 10.1155/2017/6935648.
24. Raza N, Sarwar I, Munazza B, Ayub M, Suleman M. Assessment of iron deficiency in pregnant women by determining iron status. J Ayub Med Coll Abbottabad. 2011;23(2):36–40.
25. Lopez A, Cacoub P, Macdougall IC, Peyrin-Biroulet L. Iron deficiency anaemia. Lancet. 2016;387(10021):907–16. doi: 10.1016/S0140-6736(15)60865-0
Additional Files
Published
How to Cite
Issue
Section
License
Copyright (c) 2020 jahanzaib lashari, Zahid Anwar, Tahira ghazenfer, Mehreen lashari
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Articles published in the Journal of Dow University of Health Sciences are distributed under the terms of the Creative Commons Attribution Non-Commercial License https://creativecommons.org/ licenses/by-nc/4.0/. This license permits use, distribution and reproduction in any medium; provided the original work is properly cited and initial publication in this journal.