Synergistic Effects of Omeprazole and Metformin on Glycemic Control in Type 2 Diabetic Patients. A Randomized Clinical Study

Fizzah Ali, Moosa Khan, Kausar Aamir, Muhammad Azhar Mughal


Objective: To evaluate the synergistic effects of omeprazole and metformin on glycemic control among patients
with type 2 diabetes.
Method: This randomized interventional clinical study was conducted in the Department of Pharmacology and
Therapeutics, Basic Medical Sciences Institute, Jinnah post graduate medical Centre Karachi. Total study period
was 10 months (august 2014-June2015) with individual study period of 3 months (90 days), Eighty(80) type
2 diabetic patients (40 in each group) of either sex, ages ranged from 30 to 60 years without any known comorbidities
were included. Group-A was treated with metformin alone and Group-B was treated with metformin
plus omeprazole. Efficacy was evaluated by means of FBG, and HbA1C.
Results: Out of 80 patients, 74 had completed the study. Group B showed significant reduction (P=0.001) in
terms of FBS and HbA1c level when comparison was done on day 90 with Group A and within group as
compared to day 0.
Conclusion:-Addition of proton pump inhibitor with metformin was found effective in achieving better glycemic
control in type 2 diabetic patients.


Proton pump inhibitor, omeprazole, metformin, HbA1C, FBG, SGPT.

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