Diagnostic Accuracy of Contrast Enhanced Computed Tomography in Detecting Bronchogenic Carcinoma-Experience At Liaquat National Hospital

Nazish Khaliq, Ameet Jesrani, Muhammad Ayub Mansoor, Waseem Mehmood Nizamani, Roomi Mahmud, Mustansir H. Zaidi


Background: Lung cancer is one of the most common malignancies worldwide. Cigarette smoking is considered
as the major risk factor for bronchogenic carcinoma. The four common types namely – squamous cell; small
cell; adeno and large cell carcinomas account for more than 90% cases of Bronchogenic carcinoma. Initially
it is detected by plain chest radiography but it is considered as an insensitive. Computed Tomography can detect
early stage disease 6-10 times more frequently than X-rays.
Objective: To determine diagnostic accuracy of Contrast Enhanced Computed Tomography in detecting
Bronchogenic Carcinoma taking histopathology as Gold Standard.
Methods: Total 157 patients presented with pulmonary nodule or suspicious lesion on X-Ray and had history
of haemoptysis, weight loss, cough and chest pain for more than two months were included. CT was performed
with I/V contrast. Axial images were taken with patients lying supine. Images were analyzed. The same
radiologist assessed the patient included in the study. All patients then underwent biopsy and samples were
sent for histopathology. Sensitivity, specificity, and accuracy of computed tomography were calculated using
histopathology as gold standard.
Results: There were 101 male and 56 female patients. The mean age was 59.77±7.97 years. On CT Scan 89
patients were diagnosed with bronchogenic carcinoma. On histopathology, 90 patients were diagnosed with
bronchogenic carcinoma. The sensitivity of CT Scan was 90.0%, specificity was 88.0% and diagnostic accuracy
was 89.1%.
Conclusion: CT scan is a sensitive imaging modality in diagnosing malignancy in pulmonary lesions


Diagnostic Accuracy, bronchogenic carcinoma, CT Scan, Histopathology

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