Outcomes of Antibiotics as Primary Therapy in Uncomplicated Acute Appendicitis at PUMHS Nawabshah

Gulshan Ali Memon, Khawar Saeed Jamali, Syed Kashif Ali Shah, Habib ur Rehman, Shahnawaz Leghari, Shahida Baloch


Objective: Over bearing, appendectomies have continuously been pushing the surgical wisdom to connote on
non-operative option of treatment so this study was designed with an objective to assess the outcomes of
antibiotics as primary therapy for un–complicated acute appendicitis.
Methods: A total of 96 patients of both genders from 16 to 60 years of age having uncomplicated acute
appendicitis enrolled in this study were treated with antibiotics and were discharged on third day with having
oral treatment on ciprofloxacin (500mg) twice a day and metronidazole (400mg) thrice a day for 07 days.
Routine follow up was taken on days 15, 30, 90 180 and 360 and outcomes were recorded.
Results: Among 96 patients, 10 (10.41%) worsened in symptoms (pain on visual analogue scale) were confirmed
with WBC & Ultrasound reports and under went for appendectomies during initial hospital stay. While within
9 months, during follow up 11 (11.45%) patients were readmitted in hospital and operated after confirmation
on re-examination and re- investigations. Total of 21 (22%) patients were subjected to appendectomy.
Conclusion: Under proper observation, antibiotic treatment can be safe and effective in un-complicated acute
appendicitis with reduced recurrence.


Acute appendicitis, Appendectomy, Antibiotic treatment

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