LIPID PROFILE AND SERUM INSULIN LEVELS IN GESTATIONAL DIABETES

Abstract

O bjectives: To evaluate the glucose intolerance, insulin, and lipid profile in w om en who developed gestational Diabetes, compared to healthy pregnancy.
Design: Observational study Patients and M ethods: One hundred pregnant women, 50 healthy as control group and 50 already diagnosed gestational diabetic wom en as study group were selected. Plasm a fasting (FBS) and post prandial glucose
(RBS), serum insulin and serum lipid profile (total lipids, cholesterol, triglycerides, HDL-cholesterol and LDL - cholesterol) of both were monitored. Mean values were compare dusing t-test.

Results: M ean FBS [124.76±4.22 vs. 90.06±1.20 mg/dl], mean RBS [221.38±6.68 vs. 120.32±1.97 mg/dl], insulin [32.10±0.83 vs. 17.88±0.54 |!IU /m l], m ean cholesterol [216.60±5.87 vs. 166.38±3.19 mg/dl], mean triglycerides [189.36±6.76 vs. 106.28±2.85 mg/dl], LDL-cholesterol [131.08±4.73 vs. 102.48±2.18 mg/dl] and total lipids [825.24±16.92 vs. 653.96±15.40 mg/dl] were higher in GDM groups as compared to normal controls (p<0.01). M ean HDL-cholesterol [41.24±0.65 vs. 48.34±0.66 mg/dl] showed significantly lower concentration in GDM group as compared to controls (p<0.01).
Conclusion: M ean insulin and lipid levels, except HDL-cholesterol, were significantly higher in gestational
diabetics compared to controls.